169. AT-752, an Oral Guanosine Nucleotide Prodrug, Exhibits Potent in Vitro Activity Against Flaviviruses and Prevents Disease Progression in a Dengue Mouse Model

BACKGROUND: The increasing global prevalence of human Dengue virus infection and the potential for life-threatening sequelae highlight the significance of this unmet medical need. Here we report the potent in vitro activity of AT-281, the free base form of AT-752, against Dengue virus and other flav...

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Detalles Bibliográficos
Autores principales: Good, Steven S, Moussa, Adel, Zhou, Xiao-Jian, Sommadossi, Jean-Pierre, Pietropaolo, Keith
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Poster Abstracts
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7777706/
http://dx.doi.org/10.1093/ofid/ofaa439.479

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7777706/
http://dx.doi.org/10.1093/ofid/ofaa439.479

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