Interferon-mediated reprogramming of membrane cholesterol to evade bacterial toxins

Plasma membranes of animal cells are enriched for cholesterol. Cholesterol-dependent cytolysins (CDCs) are pore forming toxins secreted by bacteria that target membrane cholesterol for their effector function. Phagocytes are essential for clearance of CDC-producing bacteria; however, mechanisms thes...

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Detalles Bibliográficos
Autores principales: Zhou, Quan D., Chi, Xun, Lee, Min Sub, Hsieh, Wei Yuan, Mkrtchyan, Jonathan J., Feng, An-Chieh, He, Cuiwen, York, Autumn G, Bui, Viet L., Kronenberger, Eliza B., Ferrari, Alessandra, Xiao, Xu, Daly, Allison E., Tarling, Elizabeth J., Damoiseaux, Robert, Scumpia, Philip O., Smale, Stephen T., Williams, Kevin J., Tontonoz, Peter, Bensinger, Steven J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7778040/
https://www.ncbi.nlm.nih.gov/pubmed/32514064
http://dx.doi.org/10.1038/s41590-020-0695-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7778040/
https://www.ncbi.nlm.nih.gov/pubmed/32514064
http://dx.doi.org/10.1038/s41590-020-0695-4

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