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Argonaute NRDE-3 and MBT domain protein LIN-61 redundantly recruit an H3K9me3 HMT to prevent embryonic lethality and transposon expression

The establishment and maintenance of chromatin domains shape the epigenetic memory of a cell, with the methylation of histone H3 lysine 9 (H3K9me) defining transcriptionally silent heterochromatin. We show here that the C. elegans SET-25 (SUV39/G9a) histone methyltransferase (HMT), which catalyzes H...

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Detalles Bibliográficos
Autores principales: Padeken, Jan, Methot, Stephen, Zeller, Peter, Delaney, Colin E., Kalck, Veronique, Gasser, Susan M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7778263/
https://www.ncbi.nlm.nih.gov/pubmed/33303642
http://dx.doi.org/10.1101/gad.344234.120