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Implicating causal brain imaging endophenotypes in Alzheimer’s disease using multivariable IWAS and GWAS summary data

Recent evidence suggests the existence of many undiscovered heritable brain phenotypes involved in Alzheimer’s Disease (AD) pathogenesis. This finding necessitates methods for the discovery of causal brain changes in AD that integrate Magnetic Resonance Imaging measures and genotypic data. However,...

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Detalles Bibliográficos
Autores principales: Knutson, Katherine A., Deng, Yangqing, Pan, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7778364/
https://www.ncbi.nlm.nih.gov/pubmed/32898681
http://dx.doi.org/10.1016/j.neuroimage.2020.117347