Cargando…

Mitochondrial ROS promote mitochondrial dysfunction and inflammation in ischemic acute kidney injury by disrupting TFAM-mediated mtDNA maintenance

Aims: Ischemia-reperfusion injury (IRI)-induced acute kidney injury (IRI-AKI) is characterized by elevated levels of reactive oxygen species (ROS), mitochondrial dysfunction, and inflammation, but the potential link among these features remains unclear. In this study, we aimed to investigate the spe...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhao, Meng, Wang, Yizhuo, Li, Ling, Liu, Shuyun, Wang, Chengshi, Yuan, Yujia, Yang, Guang, Chen, Younan, Cheng, Jingqiu, Lu, Yanrong, Liu, Jingping
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Ivyspring International Publisher 2021
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7778599/ https://www.ncbi.nlm.nih.gov/pubmed/33408785 http://dx.doi.org/10.7150/thno.50905

Ejemplares similares

TFAM in mtDNA Homeostasis: Open Questions
por: Alexeyev, Mikhail
Publicado: (2023)

The cAMP phosphodiesterase Prune localizes to the mitochondrial matrix and promotes mtDNA replication by stabilizing TFAM
por: Zhang, Fan, et al.
Publicado: (2015)

Differences in Liver TFAM Binding to mtDNA and mtDNA Damage between Aged and Extremely Aged Rats
por: Chimienti, Guglielmina, et al.
Publicado: (2019)

TFAM’s Contributions to mtDNA Replication and OXPHOS Biogenesis Are Genetically Separable
por: Kozhukhar, Natalya, et al.
Publicado: (2022)

Overexpression of TFAM or Twinkle Increases mtDNA Copy Number and Facilitates Cardioprotection Associated with Limited Mitochondrial Oxidative Stress
por: Ikeda, Masataka, et al.
Publicado: (2015)

Increased TFAM binding to mtDNA damage hot spots is associated with mtDNA loss in aged rat heart
por: Chimienti, Guglielmina, et al.
Publicado: (2018)

mito-TEMPO Attenuates Oxidative Stress and Mitochondrial Dysfunction in Noise-Induced Hearing Loss via Maintaining TFAM-mtDNA Interaction and Mitochondrial Biogenesis
por: Chen, Jia-Wei, et al.
Publicado: (2022)

Mitochondrial ROS-Modulated mtDNA: A Potential Target for Cardiac Aging
por: Quan, Yue, et al.
Publicado: (2020)

Control release of mitochondria-targeted antioxidant by injectable self-assembling peptide hydrogel ameliorated persistent mitochondrial dysfunction and inflammation after acute kidney injury
por: Zhao, Meng, et al.
Publicado: (2018)

GLP-1 receptor agonist ameliorates obesity-induced chronic kidney injury via restoring renal metabolism homeostasis
por: Wang, Chengshi, et al.
Publicado: (2018)

PGC-1α alleviates mitochondrial dysfunction via TFEB-mediated autophagy in cisplatin-induced acute kidney injury
por: Yuan, Longhui, et al.
Publicado: (2021)

Activation of TFEB-mediated autophagy by trehalose attenuates mitochondrial dysfunction in cisplatin-induced acute kidney injury
por: Zhu, Lingling, et al.
Publicado: (2020)

Tfam Knockdown Results in Reduction of mtDNA Copy Number, OXPHOS Deficiency and Abnormalities in Zebrafish Embryos
por: Otten, Auke B. C., et al.
Publicado: (2020)

mtDNA, Metastasis, and the Mitochondrial Unfolded Protein Response (UPR(mt))
por: Kenny, Timothy C., et al.
Publicado: (2017)

Phloretin attenuates hyperuricemia‐induced endothelial dysfunction through co‐inhibiting inflammation and GLUT9‐mediated uric acid uptake
por: Liu, Shuyun, et al.
Publicado: (2017)

Mitochondrial DNA (mtDNA) haplotypes and dysfunctions in presbyacusis
por: MOSTAFA, H., et al.
Publicado: (2014)

Mitochondrial activity in gametes and transmission of viable mtDNA
por: Milani, Liliana, et al.
Publicado: (2015)

Mitochondrial Ophthalmoplegia Is Not Only due to mtDNA Deletions
por: Finsterer, Josef
Publicado: (2019)

TFAM knockdown-triggered mtDNA-nucleoid aggregation and a decrease in mtDNA copy number induce the reorganization of nucleoid populations and mitochondria-associated ER-membrane contacts
por: Aasumets, Koit, et al.
Publicado: (2021)

Peritoneal M2 macrophage transplantation as a potential cell therapy for enhancing renal repair in acute kidney injury
por: Mao, Ruiwen, et al.
Publicado: (2020)

Functionalized self-assembling peptide improves INS-1 β-cell function and proliferation via the integrin/FAK/ERK/cyclin pathway
por: Liu, Jingping, et al.
Publicado: (2015)

Mmm2p, a mitochondrial outer membrane protein required for yeast mitochondrial shape and maintenance of mtDNA nucleoids
por: Youngman, Matthew J., et al.
Publicado: (2004)

Macrophage-derived extracellular vesicles: diverse mediators of pathology and therapeutics in multiple diseases
por: Wang, Yizhuo, et al.
Publicado: (2020)

Mitochondrial mosaics in the liver of 3 infants with mtDNA defects
por: Roels, Frank, et al.
Publicado: (2009)

The mtDNA mutator mouse: Dissecting mitochondrial involvement in aging
por: Edgar, Daniel, et al.
Publicado: (2009)

Mitochondrial Network State Scales mtDNA Genetic Dynamics
por: Aryaman, Juvid, et al.
Publicado: (2019)

Mitochondrial Dysfunction Associated with mtDNA in Metabolic Syndrome and Obesity
por: Todosenko, Natalia, et al.
Publicado: (2023)

Tetramethylpyrazine blocks TFAM degradation and up-regulates mitochondrial DNA copy number by interacting with TFAM
por: Lan, Linhua, et al.
Publicado: (2017)

MtDNA-maintenance defects: syndromes and genes
por: Viscomi, Carlo, et al.
Publicado: (2017)

Peritoneal M2 macrophage-derived extracellular vesicles as natural multitarget nanotherapeutics to attenuate cytokine storms after severe infections
por: Wang, Yizhuo, et al.
Publicado: (2022)

The spectrum of mitochondrial DNA (mtDNA) mutations in pediatric CNS tumors
por: Kaneva, Kristiyana, et al.
Publicado: (2021)

mtDNA Maintenance and Alterations in the Pathogenesis of Neurodegenerative Diseases
por: Shang, Dehao, et al.
Publicado: (2023)

Partial tandem duplication of mtDNA–tRNA(Phe) impairs mtDNA translation in late-onset mitochondrial myopathy
por: Arzuffi, Paola, et al.
Publicado: (2012)

Mitochondrial RNA granules are critically dependent on mtDNA replication factors Twinkle and mtSSB
por: Hensen, Fenna, et al.
Publicado: (2019)

DNA methyltransferase 1 mutations and mitochondrial pathology: is mtDNA methylated?
por: Maresca, Alessandra, et al.
Publicado: (2015)

The Author Reply: Mitochondrial Ophthalmoplegia Is Not Only due to mtDNA Deletions
por: Lee, Young-Mock
Publicado: (2019)

Mitochondrial fragmentation drives selective removal of deleterious mtDNA in the germline
por: Lieber, Toby, et al.
Publicado: (2019)

Mitochondrial diseases caused by mtDNA mutations: a mini-review
por: Ryzhkova, Anastasia I, et al.
Publicado: (2018)

Statins interfere with the attachment of S. cerevisiae mtDNA to the inner mitochondrial membrane
por: Cirigliano, Angela, et al.
Publicado: (2019)

Mitochondrial Genome (mtDNA) Mutations that Generate Reactive Oxygen Species
por: Hahn, Anne, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_98utd7mjm7r1svuu8e75327a4f