Cargando…

The β-Cell Genomic Landscape in T1D: Implications for Disease Pathogenesis

PURPOSE OF REVIEW: Type 1 diabetes (T1D) develops as a consequence of a combination of genetic predisposition and environmental factors. Combined, these events trigger an autoimmune disease that results in progressive loss of pancreatic β cells, leading to insulin deficiency. This article reviews th...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ramos-Rodríguez, Mireia, Pérez-González, Beatriz, Pasquali, Lorenzo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer US 2021
Materias:	Pathogenesis of Type 1 Diabetes (A Pugliese and SJ Richardson, Section Editors)
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7778620/ https://www.ncbi.nlm.nih.gov/pubmed/33387073 http://dx.doi.org/10.1007/s11892-020-01370-4

Ejemplares similares

The Impact of Pancreatic Beta Cell Heterogeneity on Type 1 Diabetes Pathogenesis
por: Benninger, Richard K. P., et al.
Publicado: (2018)

Lipidomic Abnormalities During the Pathogenesis of Type 1 Diabetes: a Quantitative Review
por: Suvitaival, Tommi
Publicado: (2020)

Genetic Mechanisms Highlight Shared Pathways for the Pathogenesis of Polygenic Type 1 Diabetes and Monogenic Autoimmune Diabetes
por: Johnson, Matthew B., et al.
Publicado: (2019)

Genetic and Environmental Interaction in Type 1 Diabetes: a Relationship Between Genetic Risk Alleles and Molecular Traits of Enterovirus Infection?
por: Blanter, Marfa, et al.
Publicado: (2019)

Alterations in Beta Cell Identity in Type 1 and Type 2 Diabetes
por: Moin, Abu Saleh Md, et al.
Publicado: (2019)

What the HLA-I!—Classical and Non-classical HLA Class I and Their Potential Roles in Type 1 Diabetes
por: Wyatt, Rebecca C., et al.
Publicado: (2019)

What Have Slow Progressors Taught Us About T1D—Mind the Gap!
por: Gillespie, Kathleen M., et al.
Publicado: (2019)

Human Endogenous Retroviruses and Type 1 Diabetes
por: Levet, Sandrine, et al.
Publicado: (2019)

miRNA Regulation of T Cells in Islet Autoimmunity and Type 1 Diabetes
por: Scherm, Martin G., et al.
Publicado: (2020)

Mechanisms of Beta Cell Dysfunction Associated With Viral Infection
por: Petzold, Antje, et al.
Publicado: (2015)

T Cell Receptor Profiling in Type 1 Diabetes
por: Jacobsen, Laura M., et al.
Publicado: (2017)

The Role of Epigenetics in Type 1 Diabetes
por: Jerram, Samuel T., et al.
Publicado: (2017)

Beta-cell Insufficiency
por: Kalra, Sanjay, et al.
Publicado: (2017)

Type 1 Diabetes at a Crossroads!
por: Cefalu, William T., et al.
Publicado: (2015)

Viral infection‐related gene upregulation in monocytes in children with signs of β‐cell autoimmunity
por: Valta, Milla, et al.
Publicado: (2022)

β Cell Dysfunction Versus Insulin Resistance in the Pathogenesis of Type 2 Diabetes in East Asians
por: Yabe, Daisuke, et al.
Publicado: (2015)

Mixed‐meal tolerance test to assess residual beta‐cell secretion: Beyond the area‐under‐curve of plasma C‐peptide concentration
por: Ruan, Yue, et al.
Publicado: (2019)

Increased tissue factor activity promotes thrombin generation at type 1 diabetes onset in children
por: Jasser‐Nitsche, Hildegard, et al.
Publicado: (2020)

Identification of infants with increased type 1 diabetes genetic risk for enrollment into Primary Prevention Trials—GPPAD‐02 study design and first results
por: Winkler, Christiane, et al.
Publicado: (2019)

Celiac disease can be predicted by high levels of tissue transglutaminase antibodies in children and adolescents with type 1 diabetes
por: Cerqueiro Bybrant, Mara, et al.
Publicado: (2020)

Extended family history of type 1 diabetes in HLA‐predisposed children with and without islet autoantibodies
por: Kuusela, Salla, et al.
Publicado: (2020)

Human plasma‐derived alpha(1)‐proteinase inhibitor in patients with new‐onset type 1 diabetes mellitus: A randomized, placebo‐controlled proof‐of‐concept study
por: Lagarde, William H., et al.
Publicado: (2020)

Associations between deduced first islet specific autoantibody with sex, age at diagnosis and genetic risk factors in young children with type 1 diabetes
por: Ilonen, Jorma, et al.
Publicado: (2022)

Antibiotic treatment during early childhood and risk of type 1 diabetes in children: A national birth cohort study
por: Antvorskov, Julie Christine, et al.
Publicado: (2020)

HbA1c as a time predictive biomarker for an additional islet autoantibody and type 1 diabetes in seroconverted TEDDY children
por: Salami, Falastin, et al.
Publicado: (2022)

Insulin resistance relates to DKA severity and affects insulin requirement in children with type 1 diabetes at onset
por: Mastromauro, Concetta, et al.
Publicado: (2022)

Ten Years of Vildagliptin
por: Del Prato, Stefano
Publicado: (2017)

The Vildagliptin Experience — 25 Years Since the Initiation of the Novartis Glucagon-like Peptide-1 Based Therapy Programme and 10 Years Since the First Vildagliptin Registration
por: Foley, James E, et al.
Publicado: (2017)

Dipeptidyl Peptidase-4 Inhibitor Development and Post-authorisation Programme for Vildagliptin — Clinical Evidence for Optimised Management of Chronic Diseases Beyond Type 2 Diabetes
por: Strain, William David, et al.
Publicado: (2017)

Clinical Safety and Tolerability of Vildagliptin — Insights from Randomised Trials, Observational Studies and Post-marketing Surveillance
por: Mathieu, Chantal, et al.
Publicado: (2017)

Substitution among milk and yogurt products and the risk of incident type 2 diabetes in the EPIC‐NL cohort
por: Stuber, J. M., et al.
Publicado: (2020)

Effects of potato resistant starch intake on insulin sensitivity, related metabolic markers and appetite ratings in men and women at risk for type 2 diabetes: a pilot cross‐over randomised controlled trial
por: Sanders, L. M., et al.
Publicado: (2020)

Severe Scratching in Spinocerebellar Ataxia 17: Another Case
por: Pauly, Martje G., et al.
Publicado: (2020)

Clinical Spectrum of Drug-Induced Movement Disorders: A Study of 97 Patients
por: Gupta, Harsh V., et al.
Publicado: (2020)

Late-Onset Tay-Sachs Disease - expanding the clinical phenotype
por: Lefter, Stela, et al.
Publicado: (2023)

Genetic association analyses of atopic illness and proinflammatory cytokine genes with type 1 diabetes
por: Saleh, Nada M, et al.
Publicado: (2011)

Lower HbA1c in patients with type 1 diabetes and celiac disease who reached celiac‐specific antibody‐negativity—A multicenter DPV analysis
por: Nagl, Katrin, et al.
Publicado: (2019)

Size matters: Influence of center size on quality of diabetes control in children and adolescents with type 1 diabetes—A longitudinal analysis of the DPV cohort
por: Hackl, Lukas, et al.
Publicado: (2021)

Management of Type 1 Diabetes in Pregnancy
por: Feldman, Anna Z., et al.
Publicado: (2016)

A Review of Insulin-Dosing Formulas for Continuous Subcutaneous Insulin Infusion (CSII) for Adults with Type 1 Diabetes
por: King, Allen B., et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_0krnt7ac9k63mhhbqckln0g6gu