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Loss of metabolic flexibility as a result of overexpression of pyruvate dehydrogenase kinases in muscle, liver and the immune system: Therapeutic targets in metabolic diseases

Good health depends on the maintenance of metabolic flexibility, which in turn is dependent on the maintenance of regulatory flexibility of a large number of regulatory enzymes, but especially the pyruvate dehydrogenase complex (PDC), because of its central role in carbohydrate metabolism. Flexibili...

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Detalles Bibliográficos
Autores principales: Jeon, Jae‐Han, Thoudam, Themis, Choi, Eun Jung, Kim, Min‐Ji, Harris, Robert A, Lee, In‐Kyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7779278/
https://www.ncbi.nlm.nih.gov/pubmed/32628351
http://dx.doi.org/10.1111/jdi.13345