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Deimmunization of protein therapeutics – Recent advances in experimental and computational epitope prediction and deletion
Biotherapeutics, and antimicrobial proteins in particular, are of increasing interest for human medicine. An important challenge in the development of such therapeutics is their potential immunogenicity, which can induce production of anti-drug-antibodies, resulting in altered pharmacokinetics, redu...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Research Network of Computational and Structural Biotechnology
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7779837/ https://www.ncbi.nlm.nih.gov/pubmed/33425259 http://dx.doi.org/10.1016/j.csbj.2020.12.024 |