AMP‐activated protein kinase activation primes cytoplasmic translocation and autophagic degradation of the BCR‐ABL protein in CML cells

Chronic myeloid leukemia is driven by the BCR‐ABL oncoprotein, a constitutively active protein tyrosine kinase. Although tyrosine kinase inhibitors (TKIs) have greatly improved the prognosis of CML patients, the emergence of TKI resistance is an important clinical problem, which deserves additional...

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Detalles Bibliográficos
Autores principales: Koyama, Daisuke, Kikuchi, Jiro, Kuroda, Yoshiaki, Ohta, Masatsugu, Furukawa, Yusuke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Cell, Molecular, and Stem Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7780059/
https://www.ncbi.nlm.nih.gov/pubmed/33070465
http://dx.doi.org/10.1111/cas.14698

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7780059/
https://www.ncbi.nlm.nih.gov/pubmed/33070465
http://dx.doi.org/10.1111/cas.14698

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