Rapamycin and abundant TCR stimulation are required for the generation of stable human induced regulatory T cells

OBJECTIVES: Regulatory T cells (Tregs) are a vital sub‐population of CD4(+) T cells with major roles in immune tolerance and homeostasis. Given such properties, the use of regulatory T cells for immunotherapies has been extensively investigated, with a focus on adoptive transfer of ex vivo expanded...

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Detalles Bibliográficos
Autores principales: Kim, Juewan, Hope, Christopher M, Perkins, Griffith B, Stead, Sebastian O, Scaffidi, Jacqueline C, Kette, Francis D, Carroll, Robert P, Barry, Simon C, Coates, Patrick Toby
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7780108/
https://www.ncbi.nlm.nih.gov/pubmed/33425354
http://dx.doi.org/10.1002/cti2.1223

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7780108/
https://www.ncbi.nlm.nih.gov/pubmed/33425354
http://dx.doi.org/10.1002/cti2.1223

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