CLIP and Massively Parallel Functional Analysis of CELF6 Reveal a Role in Destabilizing Synaptic Gene mRNAs through Interaction with 3′ UTR Elements

CELF6 is a CELF-RNA-binding protein, and thus part of a protein family with roles in human disease; however, its mRNA targets in the brain are largely unknown. Using cross-linking immunoprecipitation and sequencing (CLIP-seq), we define its CNS targets, which are enriched for 3′ UTRs in synaptic pro...

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Detalles Bibliográficos
Autores principales: Rieger, Michael A., King, Dana M., Crosby, Haley, Liu, Yating, Cohen, Barak A., Dougherty, Joseph D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7780154/
https://www.ncbi.nlm.nih.gov/pubmed/33357440
http://dx.doi.org/10.1016/j.celrep.2020.108531

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7780154/
https://www.ncbi.nlm.nih.gov/pubmed/33357440
http://dx.doi.org/10.1016/j.celrep.2020.108531

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