Progranulin induces immune escape in breast cancer via up-regulating PD-L1 expression on tumor-associated macrophages (TAMs) and promoting CD8(+) T cell exclusion

BACKGROUND: Progranulin (PGRN), as a multifunctional growth factor, is overexpressed in multiple tumors, but the role of PGRN on tumor immunity is still unclear. Here, we studied the effect of PGRN on breast cancer tumor immunity and its possible molecular mechanism. METHODS: The changes of macropha...

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Detalles Bibliográficos
Autores principales: Fang, Wenli, Zhou, Ting, Shi, He, Yao, Mengli, Zhang, Dian, Qian, Husun, Zeng, Qian, Wang, Yange, Jin, Fangfang, Chai, Chengsen, Chen, Tingmei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7780622/
https://www.ncbi.nlm.nih.gov/pubmed/33390170
http://dx.doi.org/10.1186/s13046-020-01786-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7780622/
https://www.ncbi.nlm.nih.gov/pubmed/33390170
http://dx.doi.org/10.1186/s13046-020-01786-6

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