O6-methylguanine-DNA methyltransferase modulates cisplatin-induced DNA double-strand breaks by targeting the homologous recombination pathway in nasopharyngeal carcinoma

BACKGROUND: The homologous recombination (HR) pathway is involved in DNA damage response (DDR), which is crucial to cancer cell survival after treatment with DNA damage agents. O6-methylguanine DNA methyltransferase (MGMT) is associated with cisplatin (CDDP) resistance in cancer cells; however, the...

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Detalles Bibliográficos
Autores principales: Chen, Shang-Hung, Huang, Wen-Tsung, Kao, Wan-Chen, Hsiao, Sheng-Yen, Pan, Hsin-Yi, Fang, Chin-Wen, Shiue, Yow-Ling, Chou, Chia-Lin, Li, Chien-Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7780675/
https://www.ncbi.nlm.nih.gov/pubmed/33397362
http://dx.doi.org/10.1186/s12929-020-00699-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7780675/
https://www.ncbi.nlm.nih.gov/pubmed/33397362
http://dx.doi.org/10.1186/s12929-020-00699-y

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