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O6-methylguanine-DNA methyltransferase modulates cisplatin-induced DNA double-strand breaks by targeting the homologous recombination pathway in nasopharyngeal carcinoma

BACKGROUND: The homologous recombination (HR) pathway is involved in DNA damage response (DDR), which is crucial to cancer cell survival after treatment with DNA damage agents. O6-methylguanine DNA methyltransferase (MGMT) is associated with cisplatin (CDDP) resistance in cancer cells; however, the...

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Detalles Bibliográficos
Autores principales:	Chen, Shang-Hung, Huang, Wen-Tsung, Kao, Wan-Chen, Hsiao, Sheng-Yen, Pan, Hsin-Yi, Fang, Chin-Wen, Shiue, Yow-Ling, Chou, Chia-Lin, Li, Chien-Feng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7780675/ https://www.ncbi.nlm.nih.gov/pubmed/33397362 http://dx.doi.org/10.1186/s12929-020-00699-y

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