Simvastatin profoundly impairs energy metabolism in primary human muscle cells

OBJECTIVES: Simvastatin use is associated with muscular side effects, and increased risk for type 2 diabetes (T2D). In clinical use, simvastatin is administered in inactive lipophilic lactone-form, which is then converted to active acid-form in the body. Here, we have investigated if lactone- and ac...

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Detalles Bibliográficos
Autores principales: Mäkinen, Selina, Datta, Neeta, Nguyen, Yen H, Kyrylenko, Petro, Laakso, Markku, Koistinen, Heikki A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bioscientifica Ltd 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7780958/
https://www.ncbi.nlm.nih.gov/pubmed/33295884
http://dx.doi.org/10.1530/EC-20-0444

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7780958/
https://www.ncbi.nlm.nih.gov/pubmed/33295884
http://dx.doi.org/10.1530/EC-20-0444

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