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Simvastatin profoundly impairs energy metabolism in primary human muscle cells
OBJECTIVES: Simvastatin use is associated with muscular side effects, and increased risk for type 2 diabetes (T2D). In clinical use, simvastatin is administered in inactive lipophilic lactone-form, which is then converted to active acid-form in the body. Here, we have investigated if lactone- and ac...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Bioscientifica Ltd
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7780958/ https://www.ncbi.nlm.nih.gov/pubmed/33295884 http://dx.doi.org/10.1530/EC-20-0444 |