Failure to replicate the association of rare loss-of-function variants in type I IFN immunity genes with severe COVID-19

A recent report found that rare predicted loss-of-function (pLOF) variants across 13 candidate genes in TLR3- and IRF7-dependent type I IFN pathways explain up to 3.5% of severe COVID-19 cases. We performed whole-exome or whole-genome sequencing of 1,934 COVID-19 cases (713 with severe and 1,221 wit...

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Detalles Bibliográficos
Autores principales: Povysil, Gundula, Butler-Laporte, Guillaume, Shang, Ning, Weng, Chen, Khan, Atlas, Alaamery, Manal, Nakanishi, Tomoko, Zhou, Sirui, Forgetta, Vincenzo, Eveleigh, Robert, Bourgey, Mathieu, Aziz, Naveed, Jones, Steven, Knoppers, Bartha, Scherer, Stephen, Strug, Lisa, Lepage, Pierre, Ragoussis, Jiannis, Bourque, Guillaume, Alghamdi, Jahad, Aljawini, Nora, Albes, Nour, Al-Afghani, Hani M., Alghamdi, Bader, Almutair, Mansour, Mahmoud, Ebrahim Sabri, Safie, Leen Abu, Bardisy, Hadeel El, Al Harthi, Fawz S., Alshareef, Abdulraheem, Suliman, Bandar Ali, Alqahtani, Saleh, AlMalik, Abdulaziz, Alrashed, May M., Massadeh, Salam, Mooser, Vincent, Lathrop, Mark, Arabi, Yaseen, Mbarek, Hamdi, Saad, Chadi, Al-Muftah, Wadha, Badji, Radja, Al Thani, Asma, Ismail, Said I., Gharavi, Ali G., Abedalthagafi, Malak S., Richards, J Brent, Goldstein, David B., Kiryluk, Krzysztof
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7781338/
https://www.ncbi.nlm.nih.gov/pubmed/33398295
http://dx.doi.org/10.1101/2020.12.18.20248226

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7781338/
https://www.ncbi.nlm.nih.gov/pubmed/33398295
http://dx.doi.org/10.1101/2020.12.18.20248226

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