A mechanistic model of the BLADE platform predicts performance characteristics of 256 different synthetic DNA recombination circuits

Boolean logic and arithmetic through DNA excision (BLADE) is a recently developed platform for implementing inducible and logical control over gene expression in mammalian cells, which has the potential to revolutionise cell engineering for therapeutic applications. This 2-input 2-output platform ca...

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Detalles Bibliográficos
Autores principales: Bowyer, Jack E., Ding, Chloe, Weinberg, Benjamin H., Wong, Wilson W., Bates, Declan G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7781486/
https://www.ncbi.nlm.nih.gov/pubmed/33338034
http://dx.doi.org/10.1371/journal.pcbi.1007849

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7781486/
https://www.ncbi.nlm.nih.gov/pubmed/33338034
http://dx.doi.org/10.1371/journal.pcbi.1007849

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