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A mechanistic model of the BLADE platform predicts performance characteristics of 256 different synthetic DNA recombination circuits
Boolean logic and arithmetic through DNA excision (BLADE) is a recently developed platform for implementing inducible and logical control over gene expression in mammalian cells, which has the potential to revolutionise cell engineering for therapeutic applications. This 2-input 2-output platform ca...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7781486/ https://www.ncbi.nlm.nih.gov/pubmed/33338034 http://dx.doi.org/10.1371/journal.pcbi.1007849 |