Mechanistic insights into volatile anesthetic modulation of K2P channels

K2P potassium channels are known to be modulated by volatile anesthetic (VA) drugs and play important roles in clinically relevant effects that accompany general anesthesia. Here, we utilize a photoaffinity analog of the VA isoflurane to identify a VA-binding site in the TREK1 K2P channel. The funct...

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Detalles Bibliográficos
Autores principales: Wague, Aboubacar, Joseph, Thomas T, Woll, Kellie A, Bu, Weiming, Vaidya, Kiran A, Bhanu, Natarajan V, Garcia, Benjamin A, Nimigean, Crina M, Eckenhoff, Roderic G, Riegelhaupt, Paul M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7781597/
https://www.ncbi.nlm.nih.gov/pubmed/33345771
http://dx.doi.org/10.7554/eLife.59839

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7781597/
https://www.ncbi.nlm.nih.gov/pubmed/33345771
http://dx.doi.org/10.7554/eLife.59839

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