Glycoengineering of AAV-delivered monoclonal antibodies yields increased ADCC activity

The absence of fucose on asparagine-297 of the human immunoglobulin G (IgG) heavy chain has been shown to enhance antibody-dependent cellular cytotoxicity (ADCC) activity by 10- to 100-fold compared to fucosylated antibody. Our lab is studying the use of adeno-associated virus (AAV) as a vector for...

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Detalles Bibliográficos
Autores principales: Termini, James M., Martinez-Navio, José M., Gao, Guangping, Fuchs, Sebastian P., Desrosiers, Ronald C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2020
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7782200/
https://www.ncbi.nlm.nih.gov/pubmed/33426147
http://dx.doi.org/10.1016/j.omtm.2020.11.001

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7782200/
https://www.ncbi.nlm.nih.gov/pubmed/33426147
http://dx.doi.org/10.1016/j.omtm.2020.11.001

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