Longitudinal PET Imaging to Monitor Treatment Efficacy by Liposomal Irinotecan in Orthotopic Patient-Derived Pancreatic Tumor Models of High and Low Hypoxia

PURPOSE: Hypoxia is linked to aggressiveness, resistance to therapy, and poor prognosis of pancreatic tumors. Liposomal irinotecan (nal-IRI, ONIVYDE®) has shown potential in reducing hypoxia in the HT29 colorectal cancer model, and here, we investigate its therapeutic activity and ability to modulat...

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Detalles Bibliográficos
Autores principales: Ventura, Manuela, Bernards, Nicholas, De Souza, Raquel, Fricke, Inga B., Hendriks, Bart S., Fitzgerald, Jonathan B., Lee, Helen, Klinz, Stephan G., Zheng, Jinzi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7782415/
https://www.ncbi.nlm.nih.gov/pubmed/31482415
http://dx.doi.org/10.1007/s11307-019-01374-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7782415/
https://www.ncbi.nlm.nih.gov/pubmed/31482415
http://dx.doi.org/10.1007/s11307-019-01374-x

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