Targeting PAI-1 in Cardiovascular Disease: Structural Insights Into PAI-1 Functionality and Inhibition

Plasminogen activator inhibitor-1 (PAI-1), a member of the serine protease inhibitor (serpin) superfamily with antiprotease activity, is the main physiological inhibitor of tissue-type (tPA) and urokinase-type (uPA) plasminogen activators (PAs). Apart from being crucially involved in fibrinolysis an...

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Detalles Bibliográficos
Autores principales: Sillen, Machteld, Declerck, Paul J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Cardiovascular Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7782431/
https://www.ncbi.nlm.nih.gov/pubmed/33415130
http://dx.doi.org/10.3389/fcvm.2020.622473

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7782431/
https://www.ncbi.nlm.nih.gov/pubmed/33415130
http://dx.doi.org/10.3389/fcvm.2020.622473

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