Insulin receptor substrate-1 (IRS-1) mediates progesterone receptor-driven stemness and endocrine resistance in oestrogen receptor+ breast cancer

BACKGROUND: Progesterone receptors (PR) are potent modifiers of endocrine responses. In aberrant signalling cancer contexts, phosphorylation events dramatically alter steroid hormone receptor action. METHODS: The transcriptomes of primary tumours and metastases in mice harbouring ER+ breast cancer p...

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Detalles Bibliográficos
Autores principales: Dwyer, Amy R., Truong, Thu H., Kerkvliet, Carlos Perez, Paul, Kiran V., Kabos, Peter, Sartorius, Carol A., Lange, Carol A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7782753/
https://www.ncbi.nlm.nih.gov/pubmed/33144693
http://dx.doi.org/10.1038/s41416-020-01094-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7782753/
https://www.ncbi.nlm.nih.gov/pubmed/33144693
http://dx.doi.org/10.1038/s41416-020-01094-y

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