Rate volatility and asymmetric segregation diversify mutation burden in cells with mutator alleles

Mutations that compromise mismatch repair (MMR) or DNA polymerase ε or δ exonuclease domains produce mutator phenotypes capable of fueling cancer evolution. Here, we investigate how combined defects in these pathways expands genetic heterogeneity in cells of the budding yeast, Saccharomyces cerevisi...

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Detalles Bibliográficos
Autores principales: Dowsett, Ian T., Sneeden, Jessica L., Olson, Branden J., McKay-Fleisch, Jill, McAuley, Emma, Kennedy, Scott R., Herr, Alan J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7782790/
https://www.ncbi.nlm.nih.gov/pubmed/33398111
http://dx.doi.org/10.1038/s42003-020-01544-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7782790/
https://www.ncbi.nlm.nih.gov/pubmed/33398111
http://dx.doi.org/10.1038/s42003-020-01544-6

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