Early-life-trauma triggers interferon-β resistance and neurodegeneration in a multiple sclerosis model via downregulated β1-adrenergic signaling

Environmental triggers have important functions in multiple sclerosis (MS) susceptibility, phenotype, and trajectory. Exposure to early life trauma (ELT) has been associated with higher relapse rates in MS patients; however, the underlying mechanisms are not well-defined. Here we show ELT induces me...

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Detalles Bibliográficos
Autores principales: Khaw, Yee Ming, Majid, Danish, Oh, Sungjong, Kang, Eunjoo, Inoue, Makoto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7782805/
https://www.ncbi.nlm.nih.gov/pubmed/33397973
http://dx.doi.org/10.1038/s41467-020-20302-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7782805/
https://www.ncbi.nlm.nih.gov/pubmed/33397973
http://dx.doi.org/10.1038/s41467-020-20302-0

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