Nme1 and Nme2 genes exert metastasis-suppressor activities in a genetically engineered mouse model of UV-induced melanoma

NME1 is a metastasis-suppressor gene (MSG), capable of suppressing metastatic activity in cell lines of melanoma, breast carcinoma and other cancer origins without affecting their growth in culture or as primary tumours. Herein, we selectively ablated the tandemly arranged Nme1 and Nme2 genes to ass...

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Autores principales: Pamidimukkala, Nidhi, Puts, Gemma S., Kathryn Leonard, M., Snyder, Devin, Dabernat, Sandrine, De Fabo, Edward C., Noonan, Frances P., Slominski, Andrzej, Merlino, Glenn, Kaetzel, David M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7782836/
https://www.ncbi.nlm.nih.gov/pubmed/33024267
http://dx.doi.org/10.1038/s41416-020-01096-w
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author Pamidimukkala, Nidhi
Puts, Gemma S.
Kathryn Leonard, M.
Snyder, Devin
Dabernat, Sandrine
De Fabo, Edward C.
Noonan, Frances P.
Slominski, Andrzej
Merlino, Glenn
Kaetzel, David M.
author_facet Pamidimukkala, Nidhi
Puts, Gemma S.
Kathryn Leonard, M.
Snyder, Devin
Dabernat, Sandrine
De Fabo, Edward C.
Noonan, Frances P.
Slominski, Andrzej
Merlino, Glenn
Kaetzel, David M.
author_sort Pamidimukkala, Nidhi
collection PubMed
description NME1 is a metastasis-suppressor gene (MSG), capable of suppressing metastatic activity in cell lines of melanoma, breast carcinoma and other cancer origins without affecting their growth in culture or as primary tumours. Herein, we selectively ablated the tandemly arranged Nme1 and Nme2 genes to assess their individual impacts on metastatic activity in a mouse model (HGF:p16(−/−)) of ultraviolet radiation (UVR)-induced melanoma. Metastatic activity was strongly enhanced in both genders of Nme1- and Nme2-null mice, with stronger activity in females across all genotypes. The study ascribes MSG activity to Nme2 for the first time in an in vivo model of spontaneous cancer, as well as a novel metastasis-suppressor function to Nme1 in the specific context of UVR-induced melanoma.
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spelling pubmed-77828362021-01-14 Nme1 and Nme2 genes exert metastasis-suppressor activities in a genetically engineered mouse model of UV-induced melanoma Pamidimukkala, Nidhi Puts, Gemma S. Kathryn Leonard, M. Snyder, Devin Dabernat, Sandrine De Fabo, Edward C. Noonan, Frances P. Slominski, Andrzej Merlino, Glenn Kaetzel, David M. Br J Cancer Brief Communication NME1 is a metastasis-suppressor gene (MSG), capable of suppressing metastatic activity in cell lines of melanoma, breast carcinoma and other cancer origins without affecting their growth in culture or as primary tumours. Herein, we selectively ablated the tandemly arranged Nme1 and Nme2 genes to assess their individual impacts on metastatic activity in a mouse model (HGF:p16(−/−)) of ultraviolet radiation (UVR)-induced melanoma. Metastatic activity was strongly enhanced in both genders of Nme1- and Nme2-null mice, with stronger activity in females across all genotypes. The study ascribes MSG activity to Nme2 for the first time in an in vivo model of spontaneous cancer, as well as a novel metastasis-suppressor function to Nme1 in the specific context of UVR-induced melanoma. Nature Publishing Group UK 2020-10-07 2021-01-05 /pmc/articles/PMC7782836/ /pubmed/33024267 http://dx.doi.org/10.1038/s41416-020-01096-w Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Brief Communication
Pamidimukkala, Nidhi
Puts, Gemma S.
Kathryn Leonard, M.
Snyder, Devin
Dabernat, Sandrine
De Fabo, Edward C.
Noonan, Frances P.
Slominski, Andrzej
Merlino, Glenn
Kaetzel, David M.
Nme1 and Nme2 genes exert metastasis-suppressor activities in a genetically engineered mouse model of UV-induced melanoma
title Nme1 and Nme2 genes exert metastasis-suppressor activities in a genetically engineered mouse model of UV-induced melanoma
title_full Nme1 and Nme2 genes exert metastasis-suppressor activities in a genetically engineered mouse model of UV-induced melanoma
title_fullStr Nme1 and Nme2 genes exert metastasis-suppressor activities in a genetically engineered mouse model of UV-induced melanoma
title_full_unstemmed Nme1 and Nme2 genes exert metastasis-suppressor activities in a genetically engineered mouse model of UV-induced melanoma
title_short Nme1 and Nme2 genes exert metastasis-suppressor activities in a genetically engineered mouse model of UV-induced melanoma
title_sort nme1 and nme2 genes exert metastasis-suppressor activities in a genetically engineered mouse model of uv-induced melanoma
topic Brief Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7782836/
https://www.ncbi.nlm.nih.gov/pubmed/33024267
http://dx.doi.org/10.1038/s41416-020-01096-w
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