Integrated molecular characterisation of the MAPK pathways in human cancers reveals pharmacologically vulnerable mutations and gene dependencies

The mitogen-activated protein kinase (MAPK) pathways are crucial regulators of the cellular processes that fuel the malignant transformation of normal cells. The molecular aberrations which lead to cancer involve mutations in, and transcription variations of, various MAPK pathway genes. Here, we exa...

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Detalles Bibliográficos
Autores principales: Sinkala, Musalula, Nkhoma, Panji, Mulder, Nicola, Martin, Darren Patrick
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7782843/
https://www.ncbi.nlm.nih.gov/pubmed/33398072
http://dx.doi.org/10.1038/s42003-020-01552-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7782843/
https://www.ncbi.nlm.nih.gov/pubmed/33398072
http://dx.doi.org/10.1038/s42003-020-01552-6

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