Relevance of Higher-Order Epistasis in Drug Resistance

We studied five chemically distinct but related 1,3,5-triazine antifolates with regard to their effects on growth of a set of mutants in dihydrofolate reductase. The mutants comprise a combinatorially complete data set of all 16 possible combinations of four amino acid replacements associated with r...

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Detalles Bibliográficos
Autores principales: Lozovsky, Elena R, Daniels, Rachel F, Heffernan, Gavin D, Jacobus, David P, Hartl, Daniel L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Discoveries
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7782864/
https://www.ncbi.nlm.nih.gov/pubmed/32745183
http://dx.doi.org/10.1093/molbev/msaa196

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7782864/
https://www.ncbi.nlm.nih.gov/pubmed/32745183
http://dx.doi.org/10.1093/molbev/msaa196

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