Substitutions at Nonconserved Rheostat Positions Modulate Function by Rewiring Long-Range, Dynamic Interactions

Amino acid substitutions at nonconserved protein positions can have noncanonical and “long-distance” outcomes on protein function. Such outcomes might arise from changes in the internal protein communication network, which is often accompanied by changes in structural flexibility. To test this, we c...

Descripción completa

Detalles Bibliográficos
Autores principales: Campitelli, Paul, Swint-Kruse, Liskin, Ozkan, S Banu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Discoveries
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7783170/
https://www.ncbi.nlm.nih.gov/pubmed/32780837
http://dx.doi.org/10.1093/molbev/msaa202

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7783170/
https://www.ncbi.nlm.nih.gov/pubmed/32780837
http://dx.doi.org/10.1093/molbev/msaa202

Ejemplares similares