Extratubular Polymerized Uromodulin Induces Leukocyte Recruitment and Inflammation In Vivo

Uromodulin (UMOD) is produced and secreted by tubular epithelial cells. Secreted UMOD polymerizes (pUMOD) in the tubular lumen, where it regulates salt transport and protects the kidney from bacteria and stone formation. Under various pathological conditions, pUMOD accumulates within the tubular lum...

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Detalles Bibliográficos
Autores principales: Immler, Roland, Lange-Sperandio, Bärbel, Steffen, Tobias, Beck, Heike, Rohwedder, Ina, Roth, Jonas, Napoli, Matteo, Hupel, Georg, Pfister, Frederik, Popper, Bastian, Uhl, Bernd, Mannell, Hanna, Reichel, Christoph A., Vielhauer, Volker, Scherberich, Jürgen, Sperandio, Markus, Pruenster, Monika
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7783395/
https://www.ncbi.nlm.nih.gov/pubmed/33414784
http://dx.doi.org/10.3389/fimmu.2020.588245

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7783395/
https://www.ncbi.nlm.nih.gov/pubmed/33414784
http://dx.doi.org/10.3389/fimmu.2020.588245

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