Cargando…

Extratubular Polymerized Uromodulin Induces Leukocyte Recruitment and Inflammation In Vivo

Uromodulin (UMOD) is produced and secreted by tubular epithelial cells. Secreted UMOD polymerizes (pUMOD) in the tubular lumen, where it regulates salt transport and protects the kidney from bacteria and stone formation. Under various pathological conditions, pUMOD accumulates within the tubular lum...

Descripción completa

Detalles Bibliográficos
Autores principales:	Immler, Roland, Lange-Sperandio, Bärbel, Steffen, Tobias, Beck, Heike, Rohwedder, Ina, Roth, Jonas, Napoli, Matteo, Hupel, Georg, Pfister, Frederik, Popper, Bastian, Uhl, Bernd, Mannell, Hanna, Reichel, Christoph A., Vielhauer, Volker, Scherberich, Jürgen, Sperandio, Markus, Pruenster, Monika
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7783395/ https://www.ncbi.nlm.nih.gov/pubmed/33414784 http://dx.doi.org/10.3389/fimmu.2020.588245

Ejemplares similares

Src family kinase-mediated vesicle trafficking is critical for neutrophil basement membrane penetration
por: Rohwedder, Ina, et al.
Publicado: (2020)

Binding of Rap1 and Riam to Talin1 Fine-Tune β2 Integrin Activity During Leukocyte Trafficking
por: Bromberger, Thomas, et al.
Publicado: (2021)

The voltage-gated potassium channel K(V)1.3 regulates neutrophil recruitment during inflammation
por: Immler, Roland, et al.
Publicado: (2021)

E-selectin-mediated rapid NLRP3 inflammasome activation regulates S100A8/S100A9 release from neutrophils via transient gasdermin D pore formation
por: Pruenster, Monika, et al.
Publicado: (2023)

Neonatal obstructive nephropathy induces necroptosis and necroinflammation
por: Popper, Bastian, et al.
Publicado: (2019)

Serum uromodulin—a marker of kidney function and renal parenchymal integrity
por: Scherberich, Jürgen E, et al.
Publicado: (2018)

Combined Use of Serum Uromodulin and eGFR to Estimate Mortality Risk
por: Yazdani, Babak, et al.
Publicado: (2021)

Uromodulin and Estrogen
por: Intapad, Suttira
Publicado: (2023)

Sphingosine-1-phosphate receptor 3 promotes leukocyte rolling by mobilizing endothelial P-selectin
por: Nussbaum, Claudia, et al.
Publicado: (2015)

Leukocyte Trafficking and Hemostasis in the Mouse Fetus in vivo: A Practical Guide
por: Margraf, Andreas, et al.
Publicado: (2021)

Serum uromodulin is inversely associated with the metabolic syndrome in the KORA F4 study
por: Then, Cornelia, et al.
Publicado: (2019)

Extracellular MRP8/14 is a regulator of β2 integrin-dependent neutrophil slow rolling and adhesion
por: Pruenster, Monika, et al.
Publicado: (2015)

DAMPs in Unilateral Ureteral Obstruction
por: Wyczanska, Maja, et al.
Publicado: (2020)

Chronic Kidney Disease in Boys with Posterior Urethral Valves–Pathogenesis, Prognosis and Management
por: Klaus, Richard, et al.
Publicado: (2022)

Plasma Uromodulin Correlates With Kidney Function and Identifies Early Stages in Chronic Kidney Disease Patients
por: Steubl, Dominik, et al.
Publicado: (2016)

Serum uromodulin and decline of kidney function in older participants of the population-based KORA F4/FF4 study
por: Then, Cornelia, et al.
Publicado: (2020)

Radiation-induced kidney toxicity: molecular and cellular pathogenesis
por: Klaus, Richard, et al.
Publicado: (2021)

Serum uromodulin is inversely associated with biomarkers of subclinical inflammation in the population-based KORA F4 study
por: Then, Cornelia, et al.
Publicado: (2020)

Hints to the diagnosis of uromodulin kidney disease
por: Onoe, Tamehito, et al.
Publicado: (2016)

Role of Uromodulin in Salt-Sensitive Hypertension
por: Mary, Sheon, et al.
Publicado: (2022)

Sialyltransferase ST3Gal-IV controls CXCR2-mediated firm leukocyte arrest during inflammation
por: Frommhold, David, et al.
Publicado: (2008)

RAGE and ICAM-1 differentially control leukocyte recruitment during acute inflammation in a stimulus-dependent manner
por: Frommhold, David, et al.
Publicado: (2011)

Pretransplant Serum Uromodulin and Its Association with Delayed Graft Function Following Kidney Transplantation—A Prospective Cohort Study
por: Kemmner, Stephan, et al.
Publicado: (2021)

Serum uromodulin is associated with impaired glucose metabolism
por: Leiherer, Andreas, et al.
Publicado: (2017)

Serum uromodulin in dogs with chronic kidney disease
por: Seo, Dansong, et al.
Publicado: (2022)

Serum uromodulin is inversely associated with arterial hypertension and the vasoconstrictive prohormone CT-proET-1 in the population-based KORA F4 study
por: Then, Cornelia, et al.
Publicado: (2020)

Platelets Guide Leukocytes to Their Sites of Extravasation
por: Zuchtriegel, Gabriele, et al.
Publicado: (2016)

Urinary uromodulin independently predicts end-stage renal disease and rapid kidney function decline in a cohort of chronic kidney disease patients
por: Steubl, Dominik, et al.
Publicado: (2019)

Spleen tyrosine kinase Syk is critical for sustained leukocyte adhesion during inflammation in vivo
por: Frommhold, David, et al.
Publicado: (2007)

Diagnosis and Long-term Management of Uromodulin Kidney Disease
por: Wheeler, Emily, et al.
Publicado: (2019)

The Urinary Excretion of Uromodulin is Regulated by the Potassium Channel ROMK
por: Schiano, Guglielmo, et al.
Publicado: (2019)

Role of uromodulin and complement activation in the progression of kidney disease
por: Shen, Fei, et al.
Publicado: (2021)

Low serum uromodulin levels and their association with lupus flares
por: David, Bonilla-Lara, et al.
Publicado: (2022)

Uromodulin and Vesico-Ureteral Reflux: A Genetic Study
por: Maringhini, Silvio, et al.
Publicado: (2023)

Genome-wide studies reveal factors associated with circulating uromodulin and its relationships to complex diseases
por: Li, Yong, et al.
Publicado: (2022)

Comparison of clean catch and bag urine using LC–MS/MS proteomics in infants
por: Klaus, Richard, et al.
Publicado: (2023)

Uromodulin Upregulates TRPV5 by Impairing Caveolin-Mediated Endocytosis
por: Wolf, Matthias T.F., et al.
Publicado: (2013)

Urinary uromodulin, kidney function and cardiovascular disease in elderly adults
por: Garimella, Pranav S., et al.
Publicado: (2015)

P-selectin Glycoprotein Ligand-1 Mediates L-Selectin–dependent Leukocyte Rolling in Venules
por: Sperandio, Markus, et al.
Publicado: (2003)

Vitronectin stabilizes intravascular adhesion of neutrophils by coordinating b2 integrin clustering
por: Zuchtriegel, Gabriele, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_4h5pe2tiiqn45mjtdejlil7324