Pax4 Gene Delivery Improves Islet Transplantation Efficacy by Promoting β Cell Survival and α-to-β Cell Transdifferentiation

The transcription factor Pax4 plays an essential role in the development of insulin-producing β cells in pancreatic islets. Ectopic Pax4 expression not only promotes β cell survival but also induces α-to-β cell transdifferentiation. This dual functionality of Pax4 makes it an appealing therapeutic t...

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Detalles Bibliográficos
Autores principales: Parajuli, Keshab R., Zhang, Yanqing, Cao, Alexander M., Wang, Hongjun, Fonseca, Vivian A., Wu, Hongju
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2020
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7784573/
https://www.ncbi.nlm.nih.gov/pubmed/33086892
http://dx.doi.org/10.1177/0963689720958655

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7784573/
https://www.ncbi.nlm.nih.gov/pubmed/33086892
http://dx.doi.org/10.1177/0963689720958655

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