High-resolution mapping of mitotic DNA synthesis regions and common fragile sites in the human genome through direct sequencing

DNA replication stress, a feature of human cancers, often leads to instability at specific genomic loci, such as the common fragile sites (CFSs). Cells experiencing DNA replication stress may also exhibit mitotic DNA synthesis (MiDAS). To understand the physiological function of MiDAS and its relati...

Descripción completa

Detalles Bibliográficos
Autores principales: Macheret, Morgane, Bhowmick, Rahul, Sobkowiak, Katarzyna, Padayachy, Laura, Mailler, Jonathan, Hickson, Ian D., Halazonetis, Thanos D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Singapore 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7784693/
https://www.ncbi.nlm.nih.gov/pubmed/32561860
http://dx.doi.org/10.1038/s41422-020-0358-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7784693/
https://www.ncbi.nlm.nih.gov/pubmed/32561860
http://dx.doi.org/10.1038/s41422-020-0358-x

Ejemplares similares