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High-resolution mapping of mitotic DNA synthesis regions and common fragile sites in the human genome through direct sequencing
DNA replication stress, a feature of human cancers, often leads to instability at specific genomic loci, such as the common fragile sites (CFSs). Cells experiencing DNA replication stress may also exhibit mitotic DNA synthesis (MiDAS). To understand the physiological function of MiDAS and its relati...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Springer Singapore
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7784693/ https://www.ncbi.nlm.nih.gov/pubmed/32561860 http://dx.doi.org/10.1038/s41422-020-0358-x |