Cargando…

Frontotemporal dementia‐linked P112H mutation of TDP‐43 induces protein structural change and impairs its RNA binding function

TDP‐43 forms the primary constituents of the cytoplasmic inclusions contributing to various neurodegenerative diseases, including amyotrophic lateral sclerosis and frontotemporal dementia (FTD). Over 60 TDP‐43 mutations have been identified in patients suffering from these two diseases, but most var...

Descripción completa

Detalles Bibliográficos
Autores principales: Agrawal, Sashank, Jain, Monika, Yang, Wei‐Zen, Yuan, Hanna S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7784771/
https://www.ncbi.nlm.nih.gov/pubmed/33151007
http://dx.doi.org/10.1002/pro.3990