A modular framework for multiscale, multicellular, spatiotemporal modeling of acute primary viral infection and immune response in epithelial tissues and its application to drug therapy timing and effectiveness

Simulations of tissue-specific effects of primary acute viral infections like COVID-19 are essential for understanding disease outcomes and optimizing therapies. Such simulations need to support continuous updating in response to rapid advances in understanding of infection mechanisms, and parallel...

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Detalles Bibliográficos
Autores principales: Sego, T. J., Aponte-Serrano, Josua O., Ferrari Gianlupi, Juliano, Heaps, Samuel R., Breithaupt, Kira, Brusch, Lutz, Crawshaw, Jessica, Osborne, James M., Quardokus, Ellen M., Plemper, Richard K., Glazier, James A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7785254/
https://www.ncbi.nlm.nih.gov/pubmed/33347439
http://dx.doi.org/10.1371/journal.pcbi.1008451

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7785254/
https://www.ncbi.nlm.nih.gov/pubmed/33347439
http://dx.doi.org/10.1371/journal.pcbi.1008451

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