Consensus small interfering RNA targeted to stem-loops II and III of IRES structure of 5′ UTR effectively inhibits virus replication and translation of HCV sub-genotype 4a isolates from Saudi Arabia

Being the most conserved region of all hepatitis C virus (HCV) genotypes and sub-genotypes, the 5′ untranslated region (5′ UTR) of HCV genome signifies it’s importance as a potential target for anti-mRNA based treatment strategies like RNA interference. The advent and approval of first small interfe...

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Detalles Bibliográficos
Autores principales: AlMalki, Waleed H., Shahid, Imran, Abdalla, Ashraf N., Johargy, Ayman K., Ahmed, Muhammad, Hassan, Sajida
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7785429/
https://www.ncbi.nlm.nih.gov/pubmed/33424405
http://dx.doi.org/10.1016/j.sjbs.2020.11.041

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7785429/
https://www.ncbi.nlm.nih.gov/pubmed/33424405
http://dx.doi.org/10.1016/j.sjbs.2020.11.041

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