MicroRNA-195 rescues ApoE4-induced cognitive deficits and lysosomal defects in Alzheimer’s disease pathogenesis

Our recent findings link the apolipoprotein E4 (ApoE4)-specific changes in brain phosphoinositol biphosphate (PIP(2)) homeostasis to the susceptibility of developing Alzheimer’s Disease (AD). In the present study, we have identified miR-195 as a top micro-RNA candidate involved in the ApoE/PIP(2) pa...

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Detalles Bibliográficos
Autores principales: Cao, Jiqing, Huang, Min, Guo, Lei, Zhu, Li, Hou, Jianwei, Zhang, Larry, Pero, Adriana, Ng, Sabrina, El Gaamouch, Farida, Elder, Gregory, Sano, Mary, Goate, Alison, TCW, Julia, Haroutunian, Vahram, Zhang, Bin, Cai, Dongming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7785685/
https://www.ncbi.nlm.nih.gov/pubmed/32632205
http://dx.doi.org/10.1038/s41380-020-0824-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7785685/
https://www.ncbi.nlm.nih.gov/pubmed/32632205
http://dx.doi.org/10.1038/s41380-020-0824-3

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