Cargando…

Mitochondrial Calcium Uniporter Deficiency in Zebrafish Causes Cardiomyopathy With Arrhythmia

Mitochondrial Ca(2 +) uptake influences energy production, cell survival, and Ca(2 +) signaling. The mitochondrial calcium uniporter, MCU, is the primary route for uptake of Ca(2 +) into the mitochondrial matrix. We have generated a zebrafish MCU mutant that survives to adulthood and exhibits dramat...

Descripción completa

Detalles Bibliográficos
Autores principales:	Langenbacher, Adam D., Shimizu, Hirohito, Hsu, Welkin, Zhao, Yali, Borges, Alexandria, Koehler, Carla, Chen, Jau-Nian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Physiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7785991/ https://www.ncbi.nlm.nih.gov/pubmed/33424641 http://dx.doi.org/10.3389/fphys.2020.617492

Ejemplares similares

Glutamate 73 Promotes Anti-arrhythmic Effects of Voltage-Dependent Anion Channel Through Regulation of Mitochondrial Ca(2+) Uptake
por: Shimizu, Hirohito, et al.
Publicado: (2021)

Transcriptional Regulation of Heart Development in Zebrafish
por: Lu, Fei, et al.
Publicado: (2016)

The mitochondrial calcium uniporter promotes arrhythmias caused by high-fat diet
por: Joseph, Leroy C., et al.
Publicado: (2021)

Knowledge mapping of mitochondrial calcium uniporter from 2011 to 2022: A bibliometric analysis
por: Pan, Deng, et al.
Publicado: (2023)

ER stress and calcium-dependent arrhythmias
por: Hamilton, Shanna, et al.
Publicado: (2022)

Involvement of zebrafish Na(+),K(+) ATPase in myocardial cell junction maintenance
por: Cibrián-Uhalte, Elena, et al.
Publicado: (2007)

Modeling Inherited Cardiomyopathies in Adult Zebrafish for Precision Medicine
por: Ding, Yonghe, et al.
Publicado: (2020)

Inhibition of the mitochondrial calcium uniporter rescues dopaminergic neurons in pink1 (−/−) zebrafish
por: Soman, Smijin, et al.
Publicado: (2016)

The Calcineurin-FoxO-MuRF1 signaling pathway regulates myofibril integrity in cardiomyocytes
por: Shimizu, Hirohito, et al.
Publicado: (2017)

Editorial: The Role of Calcium Handling in Heart Failure and Heart Failure Associated Arrhythmias
por: Johnson, Daniel M., et al.
Publicado: (2019)

Architecture of the Mitochondrial Calcium Uniporter
por: Oxenoid, Kirill, et al.
Publicado: (2016)

In silico Identification of Disrupted Myocardial Calcium Homeostasis as Proarrhythmic Trigger in Arrhythmogenic Cardiomyopathy
por: Lyon, Aurore, et al.
Publicado: (2021)

Platelets and Cardiac Arrhythmia
por: de Jong, Jonas S. S. G., et al.
Publicado: (2010)

Regulatory mechanisms of mitochondrial calcium uptake by the calcium uniporter complex
por: Yamada, Akiko, et al.
Publicado: (2023)

Cryo-EM structure of the mitochondrial calcium uniporter
por: Nguyen, Nam X., et al.
Publicado: (2018)

The Function of the Mitochondrial Calcium Uniporter in Neurodegenerative Disorders
por: Liao, Yajin, et al.
Publicado: (2017)

Mitochondrial dysfunction, alternans, and arrhythmias
por: Aon, Miguel A.
Publicado: (2013)

Calcium Signaling and Contractility in Cardiac Myocyte of Wolframin Deficient Rats
por: Cagalinec, Michal, et al.
Publicado: (2019)

Temperature- and chemical-induced neurotoxicity in zebrafish
por: Toni, Mattia, et al.
Publicado: (2023)

Antiarrhythmic effects of ginsenoside Rg2 on calcium chloride–induced arrhythmias without oral toxicity
por: Gou, Dongxia, et al.
Publicado: (2020)

Constructing Adult Zebrafish Einthoven’s Triangle to Define Electrical Heart Axes
por: Zhao, Yali, et al.
Publicado: (2021)

Inhibition of Small Conductance Calcium-Activated Potassium (SK) Channels Prevents Arrhythmias in Rat Atria During β-Adrenergic and Muscarinic Receptor Activation
por: Skibsbye, Lasse, et al.
Publicado: (2018)

The Regulatory Roles of Mitochondrial Calcium and the Mitochondrial Calcium Uniporter in Tumor Cells
por: Zhang, Linlin, et al.
Publicado: (2022)

Editorial: Acquired and Inherited Cardiac Arrhythmias
por: Ben-Haim, Yael, et al.
Publicado: (2022)

Deficiency of Adipose Triglyceride Lipase Induces Metabolic Syndrome and Cardiomyopathy in Zebrafish
por: Lai, Hsin-Hung, et al.
Publicado: (2022)

Role of Calcium-Sensing Receptor in Mechanotransducer-Channel-Mediated Ca(2+) Influx in Hair Cells of Zebrafish Larvae
por: Lin, Li-Yih, et al.
Publicado: (2018)

Electrical recordings of the mitochondrial calcium uniporter in Xenopus oocytes
por: Tsai, Chen-Wei, et al.
Publicado: (2018)

Overexpression of Mitochondrial Calcium Uniporter Causes Neuronal Death
por: Granatiero, Veronica, et al.
Publicado: (2019)

Mechanisms of ion selectivity and throughput in the mitochondrial calcium uniporter
por: Delgado, Bryce D., et al.
Publicado: (2022)

Mitochondrial Calcium Uniporter (MCU) deficiency reveals an alternate path for Ca(2+) uptake in photoreceptor mitochondria
por: Bisbach, Celia M., et al.
Publicado: (2020)

Arrhythmia induced cardiomyopathy
por: Sugumar, Hariharan, et al.
Publicado: (2018)

Simultaneous mapping of membrane voltage and calcium in zebrafish heart in vivo reveals chamber-specific developmental transitions in ionic currents
por: Hou, Jennifer H., et al.
Publicado: (2014)

Anger, Emotion, and Arrhythmias: from Brain to Heart
por: Taggart, Peter, et al.
Publicado: (2011)

Transgenic models of cardiac arrhythmias and sudden death
por: Remme, Carol Ann
Publicado: (2013)

The involvement of TRPC3 channels in sinoatrial arrhythmias
por: Ju, Yue-Kun, et al.
Publicado: (2015)

Cardiac Arrhythmias and Antiarrhythmic Drugs: An Autophagic Perspective
por: van Bavel, Joanne J. A., et al.
Publicado: (2018)

Autonomic Neuromodulation for Preventing and Treating Ventricular Arrhythmias
por: Lai, Yanqiu, et al.
Publicado: (2019)

Cardiac Arrhythmias as Manifestations of Nanopathies: An Emerging View
por: Radwański, Przemysław B., et al.
Publicado: (2018)

Diabetes and Arrhythmias: Pathophysiology, Mechanisms and Therapeutic Outcomes
por: Grisanti, Laurel A.
Publicado: (2018)

Editorial: Ion Channel Trafficking and Cardiac Arrhythmias
por: van der Heyden, Marcel A. G., et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_2dtl91utu3i7avpcfer5hocfra