Computational modeling suggests binding-induced expansion of Epsin disordered regions upon association with AP2

Intrinsically disordered regions (IDRs) are prevalent in the eukaryotic proteome. Common functional roles of IDRs include forming flexible linkers or undergoing allosteric folding-upon-binding. Recent studies have suggested an additional functional role for IDRs: generating steric pressure on the pl...

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Detalles Bibliográficos
Autores principales: Jagannathan, N. Suhas, Hogue, Christopher W. V., Tucker-Kellogg, Lisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7787433/
https://www.ncbi.nlm.nih.gov/pubmed/33406091
http://dx.doi.org/10.1371/journal.pcbi.1008474

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7787433/
https://www.ncbi.nlm.nih.gov/pubmed/33406091
http://dx.doi.org/10.1371/journal.pcbi.1008474

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