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Computational modeling suggests binding-induced expansion of Epsin disordered regions upon association with AP2
Intrinsically disordered regions (IDRs) are prevalent in the eukaryotic proteome. Common functional roles of IDRs include forming flexible linkers or undergoing allosteric folding-upon-binding. Recent studies have suggested an additional functional role for IDRs: generating steric pressure on the pl...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7787433/ https://www.ncbi.nlm.nih.gov/pubmed/33406091 http://dx.doi.org/10.1371/journal.pcbi.1008474 |