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Polarization-sensitive stimulated Raman scattering imaging resolves amphotericin B orientation in Candida membrane

Ergosterol-targeting amphotericin B (AmB) is the first line of defense for life-threatening fungal infections. Two models have been proposed to illustrate AmB assembly in the cell membrane; one is the classical ion channel model in which AmB vertically forms transmembrane tunnel and the other is a r...

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Detalles Bibliográficos
Autores principales: Dong, Pu-Ting, Zong, Cheng, Dagher, Zeina, Hui, Jie, Li, Junjie, Zhan, Yuewei, Zhang, Meng, Mansour, Michael K., Cheng, Ji-Xin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7787481/
https://www.ncbi.nlm.nih.gov/pubmed/33523971
http://dx.doi.org/10.1126/sciadv.abd5230