Isoform-specific roles for AKT in affective behavior, spatial memory, and extinction related to psychiatric disorders

AKT is implicated in neurological disorders. AKT has three isoforms, AKT1/AKT2/AKT3, with brain cell type-specific expression that may differentially influence behavior. Therefore, we examined single Akt isoform, conditional brain-specific Akt1, and double Akt1/3 mutant mice in behaviors relevant to...

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Detalles Bibliográficos
Autores principales: Wong, Helen, Levenga, Josien, LaPlante, Lauren, Keller, Bailey, Cooper-Sansone, Andrew, Borski, Curtis, Milstead, Ryan, Ehringer, Marissa, Hoeffer, Charles
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7787664/
https://www.ncbi.nlm.nih.gov/pubmed/33325370
http://dx.doi.org/10.7554/eLife.56630

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7787664/
https://www.ncbi.nlm.nih.gov/pubmed/33325370
http://dx.doi.org/10.7554/eLife.56630

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