Cargando…
Chaperones and Ubiquitin Ligases Balance Mutant p53 Protein Stability in Esophageal and Other Digestive Cancers
The incidence of esophageal adenocarcinoma (EAC) and other gastrointestinal (GI) cancers have risen dramatically, thus defining the oncogenic drivers to develop effective therapies are necessary. Patients with Barrett’s Esophagus (BE), have an elevated risk of developing EAC. Around 70%–80% of BE ca...
Autores principales: | Martinho, May San, Nancarrow, Derek J., Lawrence, Theodore S., Beer, David G., Ray, Dipankar |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7788241/ https://www.ncbi.nlm.nih.gov/pubmed/33130332 http://dx.doi.org/10.1016/j.jcmgh.2020.10.012 |
Ejemplares similares
-
UBCH5 Family Members Differentially Impact Stabilization of Mutant p53 via RNF128 Iso1 During Barrett’s Progression to Esophageal Adenocarcinoma
por: Ray, Paramita, et al.
Publicado: (2021) -
Ubiquitin ligase TRIM71 suppresses ovarian tumorigenesis by degrading mutant p53
por: Chen, Yajie, et al.
Publicado: (2019) -
Ubiquitin ligase DTX3 empowers mutant p53 to promote ovarian cancer development
por: Wang, Shanshan, et al.
Publicado: (2020) -
The ubiquitin ligase TRIM21 regulates mutant p53 accumulation and gain of function in cancer
por: Liu, Juan, et al.
Publicado: (2023) -
Repair or destruction—an intimate liaison between ubiquitin ligases and molecular chaperones in proteostasis
por: Kevei, Éva, et al.
Publicado: (2017)