Low-pass whole genome bisulfite sequencing of neonatal dried blood spots identifies a role for RUNX1 in Down syndrome DNA methylation profiles

Neonatal dried blood spots (NDBS) are a widely banked sample source that enables retrospective investigation into early life molecular events. Here, we performed low-pass whole genome bisulfite sequencing (WGBS) of 86 NDBS DNA to examine early life Down syndrome (DS) DNA methylation profiles. DS rep...

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Detalles Bibliográficos
Autores principales: Laufer, Benjamin I, Hwang, Hyeyeon, Jianu, Julia M, Mordaunt, Charles E, Korf, Ian F, Hertz-Picciotto, Irva, LaSalle, Janine M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
General Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7788293/
https://www.ncbi.nlm.nih.gov/pubmed/33001180
http://dx.doi.org/10.1093/hmg/ddaa218

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7788293/
https://www.ncbi.nlm.nih.gov/pubmed/33001180
http://dx.doi.org/10.1093/hmg/ddaa218

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