MOAP‐1‐mediated dissociation of p62/SQSTM1 bodies releases Keap1 and suppresses Nrf2 signaling

Nrf2 signaling is vital for protecting cells against oxidative stress. However, its hyperactivation is frequently found in liver cancer through excessive build‐up of p62/SQSTM1 bodies that sequester Keap1, an adaptor of the E3‐ubiquitin ligase complex for Nrf2. Here, we report that the Bax‐binding p...

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Detalles Bibliográficos
Autores principales: Tan, Chong Teik, Chang, Hao‐Chun, Zhou, Qiling, Yu, Chundong, Fu, Nai Yang, Sabapathy, Kanaga, Yu, Victor C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7788458/
https://www.ncbi.nlm.nih.gov/pubmed/33393215
http://dx.doi.org/10.15252/embr.202050854

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7788458/
https://www.ncbi.nlm.nih.gov/pubmed/33393215
http://dx.doi.org/10.15252/embr.202050854

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