Reduced translation efficiency due to novel splicing variants in 5′ untranslated region and identification of novel cis-regulatory elements in canine and human BRCA2

BACKGROUND: Breast cancer 2, early onset (BRCA2) is a tumor suppressor gene. The protein encoded by this gene plays an important role in homologous recombination (HR)-mediated DNA repair. Deleterious mutations in BRCA2 and downregulation of its expression have been associated with tumorigenesis in d...

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Detalles Bibliográficos
Autores principales: Yoshikawa, Yasunaga, Kozuma, Hajime, Morimatsu, Masami, Sugawara, Kaori, Orino, Koichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7788759/
https://www.ncbi.nlm.nih.gov/pubmed/33407082
http://dx.doi.org/10.1186/s12860-020-00336-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7788759/
https://www.ncbi.nlm.nih.gov/pubmed/33407082
http://dx.doi.org/10.1186/s12860-020-00336-4

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