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Acquired mutations and transcriptional remodeling in long-term estrogen-deprived locoregional breast cancer recurrences
BACKGROUND: Endocrine therapy resistance is a hallmark of advanced estrogen receptor (ER)-positive breast cancer. In this study, we aimed to determine acquired genomic changes in endocrine-resistant disease. METHODS: We performed DNA/RNA hybrid-capture sequencing on 12 locoregional recurrences after...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7788918/ https://www.ncbi.nlm.nih.gov/pubmed/33407744 http://dx.doi.org/10.1186/s13058-020-01379-3 |