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Acquired mutations and transcriptional remodeling in long-term estrogen-deprived locoregional breast cancer recurrences

BACKGROUND: Endocrine therapy resistance is a hallmark of advanced estrogen receptor (ER)-positive breast cancer. In this study, we aimed to determine acquired genomic changes in endocrine-resistant disease. METHODS: We performed DNA/RNA hybrid-capture sequencing on 12 locoregional recurrences after...

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Detalles Bibliográficos
Autores principales:	Priedigkeit, Nolan, Ding, Kai, Horne, William, Kolls, Jay K., Du, Tian, Lucas, Peter C., Blohmer, Jens-Uwe, Denkert, Carsten, Machleidt, Anna, Ingold-Heppner, Barbara, Oesterreich, Steffi, Lee, Adrian V.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7788918/ https://www.ncbi.nlm.nih.gov/pubmed/33407744 http://dx.doi.org/10.1186/s13058-020-01379-3

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